The return of Det. Lupo is marred by tragedy as his seriously ill brother commits suicide with a lethal injection. But a second death by the same circumstances leads Lupo to a parolee known as Dr. Death and his daughter, who seems to be walking in her father’s footsteps. Meanwhile, a power outage is the scene of a kidnapping of an executive’s wife and daughter.

When a mother and her daughter are kidnapped during a blackout, Green and Lupo have a difficult time conducting the investigation due to the loss of power around town.

A blast uncovers a scientist who is performing controversial research, which has harmed a pregnant woman.

A defense lawyer is killed while working on a lawsuit involving a pair of missing pants. As Detectives Green and Lupo investigate, they discover a connection between the case and a large retail corporation which employs an old friend and mentor of Van Buren, who threatens the case by acting too eager and begins to cross the line.

A sensitive case of a racially motivated murder is investigated by Lupo and Green when a white male teenager and a black girl are found dead. The case soon uncovers that two brothers and the father of a local teen may be involved.

A lover’s quarrel seems to have been the motive which led to a grim murder-suicide of three roommates. But further investigation sways the case in the direction of a politically connected con man.

A missing real-estate scam artist is the prime suspect in a hit and run case. The detectives go undercover to lure the conman from hiding, with the help of a title agency employee. But the focus shifts to a surprising suspect after the sting goes bad.

The police seem to be responsible for the death of a peaceful protester at an immigration rally. With McCoy pushing his own liberal agenda and refusing to back down, the case becomes a political nightmare.

The detectives discover that a large cash withdrawal was made by a doctor just before being killed in his hotel room, while attending a convention. The investigation reveals that the murder victim was not the intended target, and that a physician is unknowingly in danger.

A prostitute and her partner seem to be the prime suspects when a high school girl is found murdered. The case gets sticky when both suspects claim each other was to blame for the crime. Later, Connie deals with an admirer of the jury pool.

Evidence points to the patients of a psychiatrist of troubled teen were intimately involved with the murdered doctor. One patient who had become his wife has been named the chief suspect.

Ties are made between a dog fighting ring, a rich wine dealer and the brutal murder of a woman.

A terrorist organization seems to be tied in with the violent death of an art dealer, until the victim's troubled son with ties to a fanatic religious group is investigated.

Det. Green is named a suspect in the shooting death of a gambler and is investigated by internal affairs, leading to the revelations of his past he has taken steps to keep quiet.

Lupo and Bernard suspect that a writer’s suicide is connected with a cult, which means trouble for Cutter when the jurors at the trial fear for their lives.

The killer of a worker who participated in a legal aid strike is defended by Connie. Connie is pitted against Cutter due to the number of attorneys picketing.

While investigating the murder of an auto mechanic, a shocking discovery is made which involves his boss and an online affair with an underage female.

While working a murder case, the District Attorney's office uncovers a scandal involving a prostitution business and the governor of New York, which may damage Jack McCoy's future as District Attorney.